Subtype of SCLC Is an Intrinsic and Persistent Feature Through Systemic Treatment.

ABSTRACT:

Introduction

SCLC is an aggressive malignancy with poor outcome. Most patients have disease recurrence despite treatments with multiple modalities. Subtyping of SCLC has been proposed recently, and novel agents targeting specific subtypes are actively being investigated. In this study, we evaluated the plasticity of subtypes in paired pre- and post-treatment samples. The aim was to understand possible subtype evolution after chemotherapy resistance that could lead to alternate targeted therapy strategies.

Methods

A total of 68 samples from 32 patients with sufficient paired specimens were identified from 1998 to 2022. ASCL1, NEUROD1, and POU2F3 immunohistochemistry studies were performed on all cases, and subtyping by predominant expression was determined. Subtype comparison

SUBMITTER: Lo YC 

PROVIDER: S-EPMC10507151 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature