Universal genome-wide association studies: Powerful joint ancestry and association testing.

ABSTRACT: The vast majority of human populations and individuals have mixed ancestry. Consequently, adjustment for locus-specific ancestry is essential for genetic association studies. To empower association studies for all populations, it is necessary to integrate effects of locus-specific ancestry and genotype. We developed a joint test of ancestry and association that can be performed with summary statistics, is independent of study design, can take advantage of locus-specific ancestry effects to boost power in association testing, and can utilize association effects to fine map admixture peaks. We illustrate the test using the association between serum triglycerides and LPL. By combining data from African Americans, European Americans, and West Africans, we identify three conditionally independe

SUBMITTER: Shriner D 

PROVIDER: S-EPMC10507155 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature