Ontology highlight
ABSTRACT:
SUBMITTER: Zibat A
PROVIDER: S-EPMC10507161 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Zibat Arne A Zhang Xiaoxiao X Dickmanns Antje A Stegmann Kim M KM Dobbelstein Adrian W AW Alachram Halima H Soliwoda Rebecca R Salinas Gabriela G Groß Uwe U Görlich Dirk D Kschischo Maik M Wollnik Bernd B Dobbelstein Matthias M
iScience 20230830 10
N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an "error catastrophe," but this bears the risk of mutated virus progeny. To address this experimentally, we propagated the initial SARS-CoV-2 strain in the presence of NHC. Deep sequencing revealed numerous NHC-induced mutations and host-cell-adapted virus variants. The presence of the neutralizing nanobody Re5D06 selected for immune esca ...[more]