CD51 labels periosteal injury-responsive osteoprogenitors.

ABSTRACT: The periosteum is a critical source of skeletal stem and progenitor cells (SSPCs) that form callus tissue in response to injury. There is yet to be a consensus on how to identify SSPCs in the adult periosteum. The aim of this study was to understand how potential murine periosteal SSPC populations behave in vivo and in response to injury. We evaluated the in vivo differentiation potential of Sca1^-CD51⁺ and Sca1⁺CD51⁺ cells following transplantation. In vitro, the Sca1⁺CD51⁺ population appears to be more primitive multipotent cells, but after transplantation, Sca1^-CD51⁺ cells showed superior engraftment, expansion, and differentiation into chondrocytes and osteoblasts. Despite repres

SUBMITTER: Cao Y 

PROVIDER: S-EPMC10507171 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature