Gut microbiota and acne: A Mendelian randomization study.

ABSTRACT:

Background

Prior observational studies have identified a relationship between the composition of gut microbiota and the onset of acne. To ascertain the causal relationship underlying this association, we adopted the Mendelian randomization (MR) method, which offers a powerful approach to causal inference.

Methods

Summary statistics on gut microbiota and acne were obtained from the MiBioGen and FinnGen consortium, respectively. The causal relationship was assessed using multiple methods in a two-sample framework, including MR Egger, weighted median, inverse variance weighted (IVW), and weighted mode. Furthermore, the heterogeneity and horizontal pleiotropy analyses were conducted, along with the leave-one-out method.

Results

The IVW estimation indicated that Allisonell

SUBMITTER: Cao Q 

PROVIDER: S-EPMC10507220 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature