Causal relationships between CD25 on immune cells and hip osteoarthritis.

ABSTRACT:

Objectives

Previous research has indicated a potential association between immune factors and osteoarthritis (OA), but the causal relationship between CD25 expression on immune cells and hip OA remains enigmatic. To shed light on this relationship, this study utilized the two-sample Mendelian Randomization (MR) method.

Methods

Leveraging genome-wide association studies (GWAS) data from the UK Biobank and arcOGEN, the investigation encompasses a substantial European cohort comprising 15,704 hip OA cases and 378,169 controls. Genetic insights into CD25 stem from a subgroup of 3,757 individuals with European ancestry, encompassing 77 CD25-related traits. Several MR methods were applied, and robustness was assessed through heterogeneity and sensitivity analysis.

Results

A

SUBMITTER: Luo H 

PROVIDER: S-EPMC10507251 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature