Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study.

ABSTRACT:

Background

Epidemiological evidence suggests an association between lifestyle habits (smoking, alcohol consumption, tea, coffee intake, etc.) and gastric cancer (GC). However, the causal relationship remains uncertain. Therefore, the purpose of this study was to ascertain whether there is a causal connection between them.

Methods

Two-sample Mendelian randomization (MR) analysis was performed using the publicly available Genome Wide Association Study summary datasets using six methods: inverse variance weighting (IVW), weighted median, MR using a Robust Adjusted Profile Score (MR.Raps), MR using a Robust Adjusted Profile Score (MR-PRESSO), Radial regression of MR, and Causal Analysis Using Summary Effect Estimates (CAUSE). A sensitivity analysis was conducted to assess the ro

SUBMITTER: Tan Y 

PROVIDER: S-EPMC10507616 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature