High-Density Lipoprotein Lipidomics and Mortality in CKD.

ABSTRACT:

Rationale & objective

Patients with chronic kidney disease (CKD) have dysfunctional high-density lipoprotein (HDL) particles that lack cardioprotective properties; altered lipid composition may be associated with these changes. To investigate HDL lipids as potential cardiovascular risk factors in CKD, we tested the associations of HDL ceramides, sphingomyelins, and phosphatidylcholines with mortality.

Study design

We leveraged data from a longitudinal prospective cohort of participants with CKD.

Setting & participants

We included participants aged greater than 21 years with CKD, excluding those on maintenance dialysis or with prior kidney transplant.

Exposure

HDL particles were isolated using density gradient ultracentrifugation. We quantified the relative abun

SUBMITTER: Lidgard B 

PROVIDER: S-EPMC10507644 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature