Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes.

ABSTRACT: Plasma levels of HDL cholesterol are inversely associated with CVD progression. It is becoming increasingly clear that HDL plays important roles in immunity that go beyond its traditionally understood roles in lipid transport. We previously reported that HDL interaction with regulatory T cells (Treg) protected them from apoptosis, which could be a mechanism underlying the broad anti-inflammatory effect of HDL. Herein, we extend our work to show that HDL interacts mainly with memory Treg, particularly with the highly suppressive effector memory Treg, by limiting caspase-dependent apoptosis in an Akt-dependent manner. Reconstitution experiments identified the protein component of HDL as the primary driver of the effect, though the most abundant HDL protein, apolipoprotein A-I (APOA1), was in

SUBMITTER: Atehortua L 

PROVIDER: S-EPMC10507648 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature