Macrophages depletion alleviates lung injury by modulating AKT3/GXP4 following ventilator associated pneumonia.

ABSTRACT:

Background

AKT3 appears to play a role in lung cancer. However, its role in ventilator-associated pneumonia is still unclear. Therefore, this study aimed to investigate the role of AKT3 in macrophages during ventilator-associated pneumonia.

Methods

The mRNA level of AKT3, Data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), The data is analyzed using the Xiantao academic analysis tool. Additionally, the roles of AKT3 in ventilator-associated pneumonia (VAP) were investigated through in vivo experiments.

Results

AKT3 was differentially expressed in various normal and tumor tissues. Functional enrichment analysis indicated the immunomodulatory function and inflammatory response of AKT3 in lung cancer. Depletion of macrophages protected against

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10507695 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature