How often does white matter hyperintensity volume regress in cerebral small vessel disease?

ABSTRACT:

Background and objectives

It has been suggested that white matter hyperintensity lesions (WMHs), which typically progress over time, can also regress, and that this might be associated with favorable cognitive performance. We determined the prevalence of WMH regression in patients with cerebral small vessel disease (SVD) and examined which demographic, clinical, and radiological markers were associated with this regression.

Methods

We used semi-automated lesion marking methods to quantify WMH volume at multiple timepoints in three cohorts with symptomatic SVD; two with moderate-to-severe symptomatic SVD (the SCANS observational cohort and the control arm of the PRESERVE interventional trial) and one with mild-to-moderate SVD (the RUN DMC observational cohort). Mixed-effects

SUBMITTER: Brown RB 

PROVIDER: S-EPMC10507994 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature