Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome.

ABSTRACT:

Background

The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC).

Methods

Protein quantitative trait loci (pQTLs) were derived from seven published genome-wide association studies (GWASs) on plasma proteome, and summary-level data were extracted for 4853 circulating protein markers. Genetic associations with CRC were obtained from a large-scale GWAS meta-analysis (16,871 cases and 26,328 controls), the FinnGen cohort (4957 cases and 304,197 controls), and the UK Biobank (9276 cases and 477,069 controls). Colocalization and summary-data-based MR (SMR) analyses were performed sequentially to verify the causal role of candida

SUBMITTER: Sun J 

PROVIDER: S-EPMC10508028 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature