Mendelian randomization analysis to analyze the genetic causality between different levels of obesity and different allergic diseases.

ABSTRACT:

Background

The causal relationship between obesity and different allergic diseases remains controversial.

Methods

The Two Sample MR package and Phenoscanner database were used to obtain and filter Genome-Wide Association Study (GWAS) data from the Open GWAS database. Mendelian randomization (MR) analysis was used to study the causal relationship between different levels of obesity and different allergic diseases. The data sets related to obesity and asthma were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened by the limma package. Cluster Profiler and GO plot packages were used for enrichment analysis to verify the results of MR analysis.

Results

Two-sample MR analysis showed a causal relationship between ob

SUBMITTER: Li Y 

PROVIDER: S-EPMC10508031 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature