Current advances in cancer vaccines targeting NY-ESO-1 for solid cancer treatment.

ABSTRACT: New York-esophageal cancer 1 (NY-ESO-1) belongs to the cancer testis antigen (CTA) family, and has been identified as one of the most immunogenic tumor-associated antigens (TAAs) among the family members. Given its ability to trigger spontaneous humoral and cellular immune response and restricted expression, NY-ESO-1 has emerged as one of the most promising targets for cancer immunotherapy. Cancer vaccines, an important element of cancer immunotherapy, function by presenting an exogenous source of TAA proteins, peptides, and antigenic epitopes to CD4⁺ T cells via major histocompatibility complex class II (MHC-II) and to CD8⁺ T cells via major histocompatibility complex class I (MHC-I). These mechanisms further enhance the immune response against TAAs med

SUBMITTER: Zhou H 

PROVIDER: S-EPMC10508181 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature