A reliable and reproducible protocol for sound-evoked vestibular myogenic potentials in rattus norvegicus.

ABSTRACT:

Introduction

Cervical vestibular evoked myogenic potentials (cVEMPs) provide an objective measure of the integrity of the sacculo-collic pathway leading to their widespread use as a clinical tool in the diagnostic vestibular test battery. Though the application of cVEMPs in preclinical models to assess vestibular function, as performed in relevant clinical populations, remains limited. The present study aimed to establish a rodent model of cVEMP with standardized methods and protocols, examine the neural basis of the responses, and characterize and validate important features for interpretation and assessment of vestibular function.

Methods

We compared air-conducted sound (ACS)-evoked VEMPs from the sternocleidomastoid muscles in naïve Brown Norway rats. A custom setup facil

SUBMITTER: Raciti FM 

PROVIDER: S-EPMC10508189 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature