Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.

ABSTRACT:

Background

The presentation, etiology, and relative risk of psychiatric disorders are strongly influenced by biological sex. Neuroticism is a transdiagnostic feature of psychiatric disorders displaying prominent sex differences. We performed genome-wide association studies of neuroticism separately in males and females to identify sex-specific genetic and transcriptomic profiles.

Methods

Neuroticism scores were derived from the Eysenck Personality Inventory Neuroticism scale. Genome-wide association studies were performed in 145,669 females and 129,229 males from the UK Biobank considering autosomal and X chromosomal variation. Two-sided z tests were used to test for sex-specific effects of discovered loci, genetic correlates (n = 673 traits), tissue and gene transcriptomic

SUBMITTER: Wendt FR 

PROVIDER: S-EPMC10508260 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature