Identifying sources of antibiotic resistance genes in the environment using the microbial Find, Inform, and Test framework.

ABSTRACT:

Introduction

Antimicrobial resistance (AMR) is an increasing public health concern for humans, animals, and the environment. However, the contributions of spatially distributed sources of AMR in the environment are not well defined.

Methods

To identify the sources of environmental AMR, the novel microbial Find, Inform, and Test (FIT) model was applied to a panel of five antibiotic resistance-associated genes (ARGs), namely, erm(B), tet(W), qnrA, sul1, and intI1, quantified from riverbed sediment and surface water from a mixed-use region.

Results

A one standard deviation increase in the modeled contributions of elevated AMR from bovine sources or land-applied waste sources [land application of biosolids, sludge, and industrial wastewater (i.e., food processing) and dom

SUBMITTER: Wiesner-Friedman C 

PROVIDER: S-EPMC10508347 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature