FCGR2B as a prognostic and immune microenvironmental marker for gliomas based on transcriptomic analysis.

ABSTRACT: To explore the expression and prognosis of Fc fragment of IgG low affinity IIb receptor (FCGR2B) in glioma and its relationship with immune microenvironment, so as to provide potential molecular targets for the treatment of glioma. We analyzed the gene expression of FCGR2B using the Cancer Genome Atlas database, Chinese Glioma Genome Atlas, Gene Expression Omnibus database and other glioma related databases. Moreover, we generated survival receiver operating characteristic curve, carried out univariate and multivariate Cox analysis and nomograph construction, and analyzed the relationship between FCGR2B and prognosis. According to the median of FCGR2B gene expression value, the differential expression analysis was carried out by high and low grouping method, and the gene ontology, Kyoto en

SUBMITTER: Sun Z 

PROVIDER: S-EPMC10508392 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature