Diverse genome-wide DNA methylation alterations in canine hepatocellular tumours.

ABSTRACT:

Background

Canine hepatocellular tumours (HCTs) are common primary liver tumours. However, the exact mechanisms of tumourigenesis remain unclear. Although some genetic mutations have been reported, DNA methylation alterations in canine HCT have not been well studied.

Objectives

In this study, we aimed to analyse the DNA methylation status of canine HCT.

Methods

Tissues from 33 hepatocellular carcinomas, 3 hepatocellular adenomas, 1 nodular hyperplasia, 21 non-tumour livers from the patients and normal livers from 5 healthy dogs were used. We analysed the DNA methylation levels of 72,367 cytosine-guanine dinucleotides (CpG sites) in all 63 samples.

Results and conclusions

Although a large fraction of CpG sites that were highly methylated in the normal liver beca

SUBMITTER: Asari Y 

PROVIDER: S-EPMC10508506 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature