Bacteria Are a Major Determinant of Orsay Virus Transmission and Infection in Caenorhabditis elegans.

ABSTRACT: The microbiota is a key determinant of the physiology and immunity of animal hosts. The factors governing the transmissibility of viruses between susceptible hosts are incompletely understood. Bacteria serve as food for Caenorhabditis elegans and represent an integral part of the natural environment of C. elegans. We determined the effects of bacteria isolated with C. elegans from its natural environment on the transmission of Orsay virus in C. elegans using quantitative virus transmission and host susceptibility assays. We observed that Ochrobactrum species promoted Orsay virus transmission, whereas Pseudomonas lurida MYb11 attenuated virus transmission relative to the standard laboratory bacterial food Escherichia coli OP50. We found that

SUBMITTER: Vassallo BG 

PROVIDER: S-EPMC10508782 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature