Lmx1a is a master regulator of the cortical hem.

ABSTRACT: Development of the nervous system depends on signaling centers - specialized cellular populations that produce secreted molecules to regulate neurogenesis in the neighboring neuroepithelium. In some cases, signaling center cells also differentiate to produce key types of neurons. The formation of a signaling center involves its induction, the maintenance of expression of its secreted molecules, and cell differentiation and migration events. How these distinct processes are coordinated during signaling center development remains unknown. By performing studies in mice, we show that Lmx1a acts as a master regulator to orchestrate the formation and function of the cortical hem (CH), a critical signaling center that controls hippocampus development. Lmx1a co-regulates CH induction, its Wnt sign

SUBMITTER: Iskusnykh IY 

PROVIDER: S-EPMC10508884 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature