Differentially activated B cells develop regulatory phenotype and show varying immunosuppressive features: a comparative study.

ABSTRACT: Regulatory B lymphocytes (Bregs) are B cells with well-pronounced immunosuppressive properties, allowing them to suppress the activity of effector cells. A broad repertoire of immunosuppressive mechanisms makes Bregs an attractive tool for adoptive cell therapy for diseases associated with excessive activation of immune reactions. Such therapy implies Breg extraction from the patient's peripheral blood, ex vivo activation and expansion, and further infusion into the patient. At the same time, the utility of Bregs for therapeutic approaches is limited by their small numbers and extremely low survival rate, which is typical for all primary B cell cultures. Therefore, extracting CD19⁺ cells from the patient's peripheral blood and specifically activating them ex vivo t

SUBMITTER: Zheremyan EA 

PROVIDER: S-EPMC10509016 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature