Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy.

ABSTRACT: Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and decreased life expectancy, yet common predisposing variation substantially contributes to the onset of the disorder, which poses an evolutionary paradox. Previous research has suggested balanced selection, a mechanism by which schizophrenia risk alleles could also provide advantages under certain environments, as a reliable explanation. However, recent studies have shown strong evidence against a positive selection of predisposing loci. Furthermore, evolutionary pressures on schizophrenia risk alleles could have changed throughout human history as new environments emerged. Here in this study, we used 1000 Genomes Project data to explore the relationship between schizophrenia predisposing loci and r

SUBMITTER: Gonzalez-Penas J 

PROVIDER: S-EPMC10509162 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature