In-vivo detection of white adipose tissue browning: a multimodality imaging approach.

ABSTRACT: Detection and differentiation of brown fat in humans poses several challenges, as this tissue is sparse and often mixed with white adipose tissue. Non-invasive detection of beige fat represents an even greater challenge as this tissue is structurally and functionally more like white fat than brown fat. Here we used positron emission tomography with ¹⁸F-fluorodeoxyglucose, computed tomography, xenon-enhanced computed tomography, and dynamic contrast-enhanced ultrasound, to non-invasively detect functional and structural changes associated with the browning process of inguinal white fat, induced in mice by chronic stimulation with the β₃-adrenergic receptor agonist CL-316243. These studies reveal a very heterogeneous increase in baseline tissue radiodensity and xenon-en

SUBMITTER: Holmes LR 

PROVIDER: S-EPMC10509182 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature