Slow wave activity across sleep-night could predict levodopa-induced dyskinesia.
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ABSTRACT:
SUBMITTER: Amato N
PROVIDER: S-EPMC10509191 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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Slow wave activity across sleep-night could predict levodopa-induced dyskinesia.
Amato Ninfa N Caverzasio Serena S Manconi Mauro M Staedler Claudio C Kaelin-Lang Alain A Galati Salvatore S
Scientific reports 20230919 1
A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID's appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decr ...[more]
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