Maternal and paternal obesity differentially reprogram the ovarian mitochondrial biogenesis of F1 female rats.

ABSTRACT: Obesity has harmful consequences on reproductive outcomes and the rapid increase in obesity is assumed to be influenced by epigenetics and trans-generation effects. Our study aimed to explore the effect of maternal and/or paternal obesity on the ovarian tissues of the first-generation female offspring in rats. The study was conducted on 40 adult Wistar albino rats (20 males and 20 females). Obesity was induced by feeding them an obesogenic diet for 3 months. The pregnancy was induced in the females by mating with males in four combinations: healthy mother with healthy father (control parents, CP), healthy mother with obese fathers (OF), obese mothers with healthy father (OM), and obese mother with obese father (obese parents, OP). After delivery, the female offspring at two months were sac

SUBMITTER: Ramadan AG 

PROVIDER: S-EPMC10509203 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature