Ontology highlight
ABSTRACT:
SUBMITTER: Forsberg BO
PROVIDER: S-EPMC10509264 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Forsberg Björn O BO Shah Pranav N M PNM Burt Alister A
Nature communications 20230919 1
Cryo electron microscopy (cryo-EM) is used by biological research to visualize biomolecular complexes in 3D, but the heterogeneity of cryo-EM reconstructions is not easily estimated. Current processing paradigms nevertheless exert great effort to reduce flexibility and heterogeneity to improve the quality of the reconstruction. Clustering algorithms are typically employed to identify populations of data with reduced variability, but lack assessment of remaining heterogeneity. Here we develope a ...[more]