Ontology highlight
ABSTRACT:
SUBMITTER: Lockwood KC
PROVIDER: S-EPMC10509311 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Lockwood Karina C KC Lear Travis B TB Rajbhandari Shristi S McKelvey Alison C AC Dunn Sarah R SR Boudreau Áine N ÁN Liu Yuan Y Chen Bill B BB
The FEBS journal 20230407 15
Dysregulated cytokine signalling is a hallmark of inflammatory bowel diseases. Inflammatory responses of the colon are regulated by the suppressor of cytokine signalling (SOCS) proteins. SOCS1 is a key member of this family, and its function is critical in maintaining an appropriate inflammatory response through the JAK/STAT signalling pathway. Dysregulation of SOCS1 protein has been identified as a causal element in colonic inflammatory diseases. Despite this, it remains unclear how SOCS1 prote ...[more]