Modeling the impact of tissue oxygen profiles and oxygen depletion parameter uncertainties on biological response and therapeutic benefit of FLASH.

ABSTRACT:

Background

Ultra-high dose rate (FLASH) radiation has been reported to efficiently suppress tumor growth while sparing normal tissue; however, the mechanism of the differential tissue sparing effect is still not known. Oxygen has long been known to profoundly impact radiobiological responses, and radiolytic oxygen depletion has been considered to be a possible cause or contributor to the FLASH phenomenon.

Purpose

This work investigates the impact of tissue pO₂ profiles, oxygen depletion per unit dose (g), and the oxygen concentration yielding half-maximum radiosensitization (the average of its maximum value and one) (k) in tumor and normal tissue.

Methods

We developed a model that considers the dependent relationship between oxygen depletion and change of r

SUBMITTER: Zhu H 

PROVIDER: S-EPMC10509320 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature