EoPred: predicting the placental phenotype of early-onset preeclampsia using public DNA methylation data.

ABSTRACT: Background: A growing body of literature has reported molecular and histological changes in the human placenta in association with preeclampsia (PE). Placental DNA methylation (DNAme) and transcriptomic patterns have revealed molecular subgroups of PE that are associated with placental histopathology and clinical phenotypes of the disease. However, the clinical and molecular heterogeneity of PE both across and within subtypes complicates the study of this disease. PE is most strongly associated with placental pathology and adverse fetal and maternal outcomes when it develops early in pregnancy. We focused on placentae from pregnancies affected by preeclampsia that were delivered before 34 weeks of gestation to develop eoPred, a predictor of the DNAme signature associated with the pl

SUBMITTER: Fernandez-Boyano I 

PROVIDER: S-EPMC10509376 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature