Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia.

ABSTRACT:

Background and hypothesis

Schizophrenia (SZ) patients display significant structural brain abnormalities; nevertheless, the genetic mechanisms regulating cortical anatomical variations and their correlation with the disease phenotype are still ambiguous.

Study design

We characterized anatomical variation using a surface-based method derived from structural magnetic resonance imaging of patients with SZ and age- and sex-matched healthy controls (HCs). Partial least-squares regression was performed across cortex regions between anatomical variation and average transcriptional profiles of SZ risk genes and all qualified genes from the Allen Human Brain Atlas. The morphological features of each brain region were correlated to symptomology variables in patients with SZ using part

SUBMITTER: Han Y 

PROVIDER: S-EPMC10509526 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature