Personalized estimates of morphometric similarity in multiple sclerosis and neuromyelitis optica spectrum disorders.

ABSTRACT: Brain morphometric alterations involve multiple brain regions on progression of the disease in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and exhibit age-related degenerative changes during the pathological aging. Recent advance in brain morphometry as measured using MRI have leveraged Person-Based Similarity Index (PBSI) approach to assess the extent of within-diagnosis similarity or heterogeneity of brain neuroanatomical profiles between individuals of healthy populations and validate in neuropsychiatric disorders. Brain morphometric changes throughout the lifespan would be invaluable for understanding regional variability of age-related structural degeneration and the substrate of inflammatory demyelinating disease. Here, we aimed to quantify the neuroana

SUBMITTER: Sun J 

PROVIDER: S-EPMC10509529 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature