Apolipoprotein M gene polymorphisms in childhood-onset type 1 diabetes in southern Brazil.

ABSTRACT: Type 1 diabetes mellitus (T1DM), associated with autoimmune destruction of pancreatic β cells, is observed in children and adolescents.

Objective

We investigated the potential association of the apolipoprotein M (APOM) polymorphisms rs707921, rs805264, rs805296, rs805297, and rs9404941 in childhood-onset T1DM (n = 144) and compared them to those in healthy (mostly Euro-Brazilian) children (n = 168).

Methods

This project was approved by the Ethics Committee of the Federal University of Parana (CAAE 24676613.6.0000.0102). Genotyping was performed using PCR-restriction fragment length polymorphisms (rs805296 and rs9404941) and TaqMan probes (rs707921, rs805264, and rs805297).

Results

All polymorphisms were in Hardy-Weinberg equilibrium. In the codomin

SUBMITTER: de Souza SW 

PROVIDER: S-EPMC10509533 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature