Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis.

ABSTRACT:

Objective

Bone morphogenetic protein receptor type 2 (BMPR2) has been associated with radiographic changes in ankylosing spondylitis (AS), but further characterization of the cellular signaling pathway in osteoprogenitor (OP) is not clearly understood. The aim of this study was to investigate the expression of BMPR2 and bone morphogenetic protein 2 (BMP2)-mediated responsibility in AS.

Methods

We collected 10 healthy control (HC) and 14 AS-OPs derived from facet joints. Subsequently, we then conducted RNA sequencing with two samples per group and selected BMP-related genes. Facet joint tissues and derived primary OPs were evaluated by validation of selected RNA sequencing data, immunohistochemistry, and comparison of osteogenic differentiation potential.

Results

Based

SUBMITTER: Jo S 

PROVIDER: S-EPMC10509643 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature