In situ forming biomaterials as muscle void fillers for the provisional treatment of volumetric muscle loss injuries.

ABSTRACT: Volumetric muscle loss (VML) represents a devastating extremity injury which leads to chronic functional deficits and disability and is unrecoverable through normal healing pathways. When left untreated, the VML pathophysiology creates many challenges towards successful treatment, such as altered residual muscle architecture, excessive fibrosis, and contracture(s). As such, innovative approaches and technologies are needed to prevent or reverse these adverse sequelae. Development of a rationally designed biomaterial technology which is intended to be acutely placed within a VML defect - i.e., to serve as a muscle void filler (MVF) by maintaining the VML defect - could address this clinical unmet need by preventing these adverse sequelae as well as enabling multi-staged treatment approaches

SUBMITTER: Clark A 

PROVIDER: S-EPMC10509707 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature