Identification and validation of a fatty acid metabolism gene signature for the promotion of metastasis in liver cancer.

ABSTRACT: Metastasis is a fatal status for liver cancer, and the identification of an effective prediction model and promising therapeutic target is essential. Given the known relationship between fatty acid (FA) metabolism and the liver, the present study aimed to investigate dysregulation of genes associated with FA metabolism in liver cancer. Bioinformatics analyses were performed on data from patients with hepatocellular carcinoma (HCC) obtained from The Cancer Genome Atlas database using R software packages. Online public tools such as the Human Protein Atlas, Tumor Immune Single-Cell Hub and the University of Alabama at Birmingham Cancer Data Analysis portal were also utilized. Some essential results were further verified using in vitro experiments using HepG2 liver cancer cells. A sign

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10509777 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature