A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations.

ABSTRACT:

Background

Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed.

Objective

We sought to detect genetic variants associated with differences in immune responsiveness against allergen components.

Methods

The participants of the present study were recruited from the Tokyo Children's Health, Illness, and Development study, and allergen component-specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen

SUBMITTER: Morii W 

PROVIDER: S-EPMC10509904 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature