Neonatal rhinorrhea, heart rate variability, and childhood exercise-induced wheeze.

ABSTRACT:

Background

There is increasing evidence linking infant rhinorrhea to school-age exercise-induced wheeze (EIW) via a parasympathetic nervous system pathway. The ratio of the root mean square of successive differences in heart beats (RMSSD) measured in quiet sleep versus active sleep (RMSSD_QS:AS) is a novel biomarker in asthma.

Objective

We tested the hypotheses that (1) neonatal rhinorrhea predicts childhood EIW independent of other neonatal respiratory symptoms, (2) neonatal RMSSD_QS:AS predicts childhood EIW, and (3) RMSSD_QS:AS mediates the association between neonatal rhinorrhea and childhood EIW.

Methods

Participants from the Safe Passage/Environmental Influences on Child Health Outcomes (PASS/ECHO) prospective birth cohort had heart

SUBMITTER: Berger S 

PROVIDER: S-EPMC10509928 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature