Associations between HLA class II alleles and IgE sensitization to allergens in the Qatar Biobank cohort.

ABSTRACT:

Background

Allergic disorders are the consequence of IgE sensitization to allergens. Population studies have shown that certain human leukocyte antigen (HLA) alleles are associated with increased or decreased risk of developing allergy.

Objective

We aimed to characterize the relationship between HLA class II allelic diversity and IgE sensitization in an understudied Arab population.

Methods

We explored associations between IgE sensitization to 7 allergen mixes and mesquite (comprising 41 food or aeroallergens) and 45 common classical HLA class II alleles in a well-defined cohort of 797 individuals representing the general adult population of Qatari nationals and long-term residents. To do so, we performed HLA calling from whole genome sequencing data at 2-field resolu

SUBMITTER: Khan T 

PROVIDER: S-EPMC10509938 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature