IgE reactivity patterns in Asian and central European cockroach-sensitized patients reveal differences in primary sensitizing allergen sources.

ABSTRACT:

Background

The prevalence of cockroach (CR) sensitization and its relevance as a trigger of allergy symptoms differs greatly in different geographic areas.

Objective

This study aimed to compare molecular IgE reactivity profiles in CR-sensitized patients with perennial allergy symptoms from Hong Kong (HK) and Austria and identify the main primary sensitizers.

Methods

IgE sensitization was assessed by skin prick test and/or IgE reactivity with CR extract. Molecular IgE reactivity profiles were analyzed via multiplex assay for sensitization to allergens and extracts from CR, house dust mite (HDM), shellfish, and 3 additional insect species.

Results

HDM was the main primary sensitizer in both cohorts. In the HK group, genuine sensitization to CR was found in 45%, b

SUBMITTER: Mittermann I 

PROVIDER: S-EPMC10509942 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature