Long-term safety and immunologic outcomes of daily oral immunotherapy for peanut allergy.

ABSTRACT:

Background

Oral immunotherapy containing peanut (Arachis hypogaea) allergen powder-dnfp (PTAH) (Palforzia [Aimmune Therapeutics, Brisbane, Calif]) for 9 to 12 months resulted in higher tolerated amounts of peanut protein in PTAH-treated individuals aged 4 to 17 years with peanut allergy than in placebo-treated participants.

Objective

We aimed to describe additional long-term pooled safety data and changes in peanut sensitization markers from baseline through approximately 5 years of treatment.

Methods

The results from 6 clinical trials of PTAH (3 controlled and 3 open-label extension studies [N = 1227]) were pooled, and analysis of safety outcomes and immunologic data was performed. The PTAH doses were administered sequentially as follows: initial dose escalati

SUBMITTER: Bird JA 

PROVIDER: S-EPMC10509957 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature