Curbside particulate matter and susceptibility to SARS-CoV-2 infection.

ABSTRACT:

Background

Biologic plausibility for the association between exposure to particulate matter (PM) less than 10 μm in aerodynamic diameter (PM₁₀) and coronavirus disease 2019 (COVID-19) morbidity in epidemiologic studies has not been determined. The upregulation of angiotensin-converting enzyme 2 (ACE2), the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) entry receptor on host cells, by PM₁₀ is a putative mechanism.

Objective

We sought to assess the effect of PM₁₀ on SARS-CoV-2 infection of cells in vitro.

Methods

PM₁₀ from the curbside of London's Marylebone Road and from exhaust emissions was collected by cyclone. A549 cells, human primary nasal epithelial cells (HPNEpCs), SARS-CoV-2-susceptible Ver

SUBMITTER: Miyashita L 

PROVIDER: S-EPMC10509961 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature