Short-chain fatty acids ameliorate allergic airway inflammation via sequential induction of PMN-MDSCs and Treg cells.

ABSTRACT:

Background

Reinforcement of the immune-regulatory pathway is a feasible strategy for prevention and therapy of allergic asthma. The short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are pleiotropic microbial fermentation products known to induce regulatory T (Treg) cells and exert an immune-regulatory effect. The cellular mechanism underlying SCFA immune regulation in asthma is not fully understood.

Objective

We investigated the role of myeloid-derived suppressor cells (MDSCs) and Treg cells, the immune-regulatory cells of innate and adaptive origin, respectively, in SCFA-elicited protection against allergic airway inflammation.

Methods

BALB/c mice were given SCFA-containing drinking water before being rendered asthmatic in response to ovalbumen. When

SUBMITTER: Huang MT 

PROVIDER: S-EPMC10509984 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature