Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13-driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells.

ABSTRACT:

Background

The immunologic mechanisms underlying pulmonary type 2 inflammation, including the dynamics of eosinophil recruitment to the lungs, still need to be elucidated.

Objective

We sought to investigate how IL-13-producing T_H2 effector cells trigger eosinophil migration in house dust mite (HDM)-driven allergic pulmonary inflammation.

Methods

Multiparameter and molecular profiling of murine lungs with HDM-induced allergy was investigated in the absence of IL-13 signaling by using IL-13Rα1-deficient mice and separately through adoptive transfer of CD4⁺ T cells from IL-5-deficient mice into TCRα^-/- mice before allergic inflammation.

Results

We demonstrated through single-cell techniques that HDM-driven pulmonary inflammation di

SUBMITTER: Gazzinelli-Guimaraes PH 

PROVIDER: S-EPMC10509988 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature