A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens.

ABSTRACT: Mycosporine-like amino acids (MAAs) are small, colorless, and water-soluble secondary metabolites. They have high molar extinction coefficients and a unique UV radiation absorption mechanism that make them effective sunscreens. Here we report the discovery of two structurally distinct MAAs from the lichen symbiont strain Nostoc sp. UHCC 0926. We identified these MAAs as aplysiapalythine E (C₂₃H₃₈N₂O₁₅) and tricore B (C₃₄H₅₃N₄O₁₅) using a combination of high-resolution liquid chromatography-mass spectrometry (HR-LCMS) analysis and nuclear magnetic resonance (NMR) spectroscopy. We obtained a 8.3 Mb complete genome sequence of Nostoc sp. UHCC 0926 to gain insights into the genetic basis for t

SUBMITTER: Arsın S 

PROVIDER: S-EPMC10510106 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature