Identification of copy number variation in Tibetan sheep using whole genome resequencing reveals evidence of genomic selection.

ABSTRACT:

Background

Copy number variation (CNV) is an important source of structural variation in the mammalian genome. CNV assays present a new method to explore the genomic diversity of environmental adaptations in animals and plants and genes associated with complex traits. In this study, the genome-wide CNV distribution characteristics of 20 Tibetan sheep from two breeds (10 Oula sheep and 10 Panou sheep) were analysed using whole-genome resequencing to investigate the variation in the genomic structure of Tibetan sheep during breeding.

Results

CNVs were detected using CNVnator, and the overlapping regions of CNVs between individual sheep were combined. Among them, a total of 60,429 CNV events were detected between the indigenous sheep breed (Oula) and the synthetic sheep breed (

SUBMITTER: Shi H 

PROVIDER: S-EPMC10510117 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature