SingleCellBase: a high-quality manually curated database of cell markers for single cell annotation across multiple species.

ABSTRACT: Annotating cells in the analysis of single-cell RNA-seq (scRNA-seq) data is one of the most challenging tasks that researchers are actively addressing. Manual cell annotation is generally considered the gold standard method, although it is labor intensive and independent of prior knowledge. At present, the relationship between high-quality, known marker genes and cell types is very limited, especially for a variety of species other than humans and mice. The singleCellBase is a manually curated resource of high-quality cell types and gene markers associations across multiple species. In details, it offers 9,158 entries spanning a total of 1,221 cell types and linking with 8,740 genes (cell markers), covering 464 diseases/status, and 165 types of tissues across 31 species. The singleCellBase

SUBMITTER: Meng FL 

PROVIDER: S-EPMC10510128 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature