Formulation of cost-effective medium and optimization studies for enhanced production of rapamycin.

ABSTRACT:

Background

Enhancing rapamycin production using a cost-effective medium is crucial for wider accessibility, reduced manufacturing costs, sustainable pharmaceutical practices, and advancements in therapeutic applications. It promotes global health, biotechnological innovation, research collaboration, and societal well-being through affordable and effective treatments. This study focuses on the development of a novel cost-effective production medium for the synthesis of rapamycin from Streptomyces hygroscopicus.

Results

In the initial screening, more rapamycin production was observed in medium A. Initially, the organism produced 10 µg/mL rapamycin. Based on the OFT results, a novel cost-effective medium composition was designed, incorporating soyabean, sugarcane juice, and dri

SUBMITTER: K Ganesh S 

PROVIDER: S-EPMC10510133 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature