Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank.

ABSTRACT:

Objectives

There is conflicting evidence around the role of sex hormones with cardiovascular outcomes. The aim of this study was to examine the association of sex hormones with the risk of myocardial infarction (MI) in pre- and post-menopausal women, and men in the UK Biobank.

Methods

The UK Biobank is a prospective population-based cohort study, that recruited over 500,000 (aged 40-69 years) women and men between 2006 and 2010. Sex specific cox regression models, estimating hazard ratios (HRs) and women to men ratio of HRs (RHR) with respective 95% confidence intervals (CI), were used to model the association of sex hormones [oestrogen, testosterone, oestrogen: testosterone (O/T) ratio, sex hormone-binding globulin (SHBG) and the free androgen index (FAI)], measured at stud

SUBMITTER: Harris K 

PROVIDER: S-EPMC10510146 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature