Perampanel's forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy.

ABSTRACT:

Background

Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy and may be under-addressed in clinical practice. Ethical concerns make it impossible to study the impact of medication nonadherence in clinical trials, but our previous work emphasizes the importance of using preclinical approaches to address these questions. With over 30 clinically available antiseizure medicines (ASM's), it remains an important question to understand the relationship between poor adherence and seizure incidence across mechanistically distinct ASM's, including the broad-spectrum ASM, perampanel (PER).

Methods

We formulated PER into chow pellets to deliver to rats in a 100% fully adherent or 50% variable nonadherent paradigm via our novel automated

SUBMITTER: Guignet M 

PROVIDER: S-EPMC10510183 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature